Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2881075 | 0.85 | ALDH1A1 (0.32) | KDM4EALDH1A1HPGDGAAKMT2A | |
| SCHEMBL2884130 | 0.83 | MAPT (0.45) | KDM4EALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL2885881 | 0.81 | EGLN1 (0.47) | L3MBTL1EGLN1 | |
| SCHEMBL2887043 | 0.81 | EGLN1 (0.47) | KDM4EALDH1A1HPGDGAAL3MBTL1 | |
| SCHEMBL2881196 | 0.80 | LMNA (0.37) | KDM4EALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL2883549 | 0.79 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDGAAL3MBTL1 | |
| SCHEMBL2887207 | 0.78 | KMT2A (0.40) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL2886100 | 0.77 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10MAPTMAPK1 | |
| SCHEMBL2883578 | 0.77 | POLB (0.39) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL2883588 | 0.76 | POLB (0.44) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124489-B1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-3124489-A1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | Fibrogen, Inc. (US) | 2017-02-01 | — | — | EP | disclosed |
| EP-2016078-B1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2016-06-15 | — | — | EP | disclosed |
| EP-1836235-B1 | POLYCARBONATES WITH FLUOROALKYLENE CARBONATE END GROUPS | SABIC INNOVATIVE PLASTICS IP (NL) | 2010-11-17 | — | — | EP | disclosed |
| US-7696223-B2 | [(2-bromo-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carbonyl)-amino]-acetic acid; modulates the stability and/or activity of hypoxia inducible factor (HIF) | FIBROGEN, INC. (US) | 2010-04-13 | — | — | US | disclosed |
| US-7687557-B2 | Polycarbonates with fluoroalkylene carbonate end groups | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2010-03-30 | — | — | US | disclosed |
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| US-20080108777-A1 | POLYCARBONATES WITH FLUOROALKYLENE CARBONATE END GROUPS | GENERAL ELECTRIC COMPANY (US) | 2008-05-08 | — | — | US | disclosed |
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2008-01-03 | — | — | US | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |
| EP-1836235-A1 | POLYCARBONATES WITH FLUOROALKYLENE CARBONATE END GROUPS | General Electric Company (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006068818-A1 | POLYCARBONATES WITH FLUOROALKYLENE CARBONATE END GROUPS | GENERAL ELECTRIC COMPANY (US) | 2006-06-29 | — | — | WO | disclosed |
| US-20060135737-A1 | Polycarbonates with fluoroalkylene carbonate end groups | CITIBANK, N.A., AS COLLATERAL AGENT | 2006-06-22 | — | — | US | disclosed |
| US-20060135662-A1 | Polycarbonates with fluoroalkylene carbonate end groups | GENERAL ELECTRIC COMPANY (US) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | HIF1AN, HIF1A, EGLN2 | KDM4E 754/4885ALDH1A1 1047/4885HPGD 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.