Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | SREBF2 | Q12772 | 5/20 | 0.33 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | FYN | P06241 | 3/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28197944 | 0.75 | PIK3CA (0.38) | JAK2S1PR1FYN | |
| SCHEMBL19996104 | 0.71 | KDM4E (0.45) | CSNK1DCSNK1E | |
| SCHEMBL19996096 | 0.70 | PRKCI (0.53) | CSNK1DCSNK1EJAK2TYK2S1PR1 | |
| SCHEMBL30504670 | 0.70 | PRKCI (0.53) | CSNK1DCSNK1EJAK2TYK2S1PR1 | |
| SCHEMBL3711754 | 0.68 | PLAU (0.47) | CSNK1DCSNK1ES1PR1S1PR3SREBF2 | |
| SCHEMBL29935002 | 0.68 | PLAU (0.47) | CSNK1DCSNK1ES1PR1S1PR3SREBF2 | |
| SCHEMBL28198655 | 0.68 | CYP11B2 (0.41) | S1PR1FYN | |
| SCHEMBL13239038 | 0.66 | CSNK1D (0.59) | CSNK1DCSNK1ES1PR1S1PR3SREBF2 | |
| SCHEMBL14291396 | 0.66 | SREBF2 (0.47) | CSNK1DCSNK1ES1PR1S1PR3SREBF2 | |
| SCHEMBL211823 | 0.66 | CSNK1D (0.40) | CSNK1DCSNK1EJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107667106-A | 2 (base of Pyrazolopyridine 3) pyrimidine derivatives as JAK inhibitor | 阿尔米雷尔有限公司 | 2018-02-06 | — | — | CN | disclosed |