Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | MME | P08473 | 2/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7522574 | 0.79 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3MEN1ALDH1A1 | |
| SCHEMBL27624000 | 0.69 | SIGMAR1 (0.42) | MAOBMEN1TSHRKMT2ASIGMAR1 | |
| SCHEMBL4749321 | 0.68 | USP2 (0.44) | SLC6A2SLC6A4MEN1CYP2C9TSHR | |
| SCHEMBL6999690 | 0.66 | USP2 (0.39) | SLC6A2SLC6A4MEN1ALDH1A1CYP2C9 | |
| SCHEMBL736076 | 0.65 | CYP2C9 (0.42) | SLC6A2SLC6A4SLC6A3MAOBMEN1 | |
| SCHEMBL8569331 | 0.65 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3SIGMAR1MME | |
| SCHEMBL11152854 | 0.65 | MAOB (0.42) | SLC6A2SLC6A4SLC6A3MAOBSIGMAR1 | |
| Hydrochloric Acid SCHEMBL4772769 | 0.64 | MEN1 (0.41) | SLC6A2SLC6A4SLC6A3MAOBMEN1 | |
| Hydrochloric Acid SCHEMBL22719342 | 0.63 | MEN1 (0.41) | SLC6A2SLC6A4SLC6A3MAOBMEN1 | |
| SCHEMBL14905909 | 0.63 | MEN1 (0.41) | SLC6A2SLC6A4SLC6A3MAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922388-A | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107787323-A | For suppressing the compound and composition of SHP2 activity | 诺华股份有限公司 | 2018-03-09 | — | — | CN | disclosed |