Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.60 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28857594 | 0.87 | LMNA (0.76) | POLBLMNAKDM4EHTTHIF1A | |
| SCHEMBL28857582 | 0.87 | LMNA (0.68) | POLBLMNAKDM4EHTTHIF1A | |
| SCHEMBL28857664 | 0.86 | KDM4E (0.68) | POLBLMNAKDM4EHTTHIF1A | |
| SCHEMBL28857579 | 0.85 | LMNA (0.70) | POLBLMNAKDM4EHTTHIF1A | |
| SCHEMBL28857649 | 0.85 | LMNA (0.78) | POLBLMNAKDM4EHTTHIF1A | |
| SCHEMBL28857644 | 0.85 | POLB (0.63) | POLBLMNAKDM4EHTTHIF1A | |
| SCHEMBL28857633 | 0.79 | KDM4E (0.67) | POLBLMNAKDM4EHTTHIF1A | |
| SCHEMBL28857646 | 0.78 | LMNA (1.00) | POLBLMNAKDM4EHTTHIF1A | |
| SCHEMBL28857600 | 0.78 | POLB (0.78) | POLBLMNAKDM4EHTTHIF1A | |
| SCHEMBL28857665 | 0.77 | HTT (1.00) | POLBLMNAKDM4EHTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160269-A | Arylcarboxamide derivatives as positive allosteric modulators of NMDAR | 北京大学 | 2022-10-11 | — | — | CN | claimed |
| CN-115160269-A | Arylcarboxamide derivatives as positive allosteric modulators of NMDAR | 北京大学 | 2022-10-11 | — | — | CN | disclosed |