SCHEMBL28858477

SCHEMBL28858477

N#Cc1ccc(C#CBr)cc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA2 P00918 3/20 0.48
CYP2A6 P11509 2/20 0.48
ALDH1A1 P00352 1/20 0.48
CA12 O43570 1/20 0.48
CA3 P07451 1/20 0.48
CA6 P23280 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
TSHR P16473 1/20 0.46
MAOA P21397 3/20 0.43
MAOB P27338 3/20 0.43
LOXL2 Q9Y4K0 2/20 0.42
MMP3 P08254 1/20 0.42
ENPP2 Q13822 1/20 0.42
GSK3B P49841 2/20 0.40
CA1 P00915 2/20 0.39
HDAC8 Q9BY41 1/20 0.39
KIF11 P52732 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2533168 0.85 APP (0.42)
SCHEMBL5607030 0.82 CA2 (0.58) CA2CYP2A6ALDH1A1CA12CA3
SCHEMBL10300311 0.82 CA2 (0.58) CA2CYP2A6ALDH1A1CA12CA3
SCHEMBL2503454 0.78 CA2 (0.69) CA2CYP2A6ALDH1A1CA12CA3
SCHEMBL45942 0.78 CA2 (0.69) CA2CYP2A6ALDH1A1CA12CA3
Water SCHEMBL28254092 0.78 CA2 (0.69) CA2CYP2A6ALDH1A1CA12CA3
Water SCHEMBL28189314 0.78 CA2 (0.69) CA2CYP2A6ALDH1A1CA12CA3
SCHEMBL30486018 0.77 CYP1A1 (0.44) MMP3KIF11
SCHEMBL8621608 0.76 MAOB (0.64) CA2CYP2A6ALDH1A1CA12CA3
SCHEMBL28303321 0.75 ENPP2 (0.45) TSHRENPP2GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115197046-B Halogenation method of unsaturated hydrocarbon 华南理工大学 2023-12-15 CN disclosed
CN-115197046-A Halogenation method of unsaturated hydrocarbon 华南理工大学 2022-10-18 CN disclosed