SCHEMBL28858725

SCHEMBL28858725

N#Cc1ccc(-c2ncco2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 2/20 0.56
LTA4H P09960 2/20 0.51
HPGDS O60760 1/20 0.44
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
CYP11B2 P19099 1/20 0.43
EGLN2 Q96KS0 1/20 0.42
MMP3 P08254 1/20 0.42
GSK3B P49841 4/20 0.41
CHRNA7 P36544 1/20 0.41
CHRNA10 Q9GZZ6 1/20 0.41
CHRNA9 Q9UGM1 1/20 0.41
GSK3A P49840 2/20 0.40
CCNB2 O95067 1/20 0.40
CDK1 P06493 1/20 0.40
CCNB1 P14635 1/20 0.40
CDK5 Q00535 1/20 0.40
CDK5R1 Q15078 1/20 0.40
CCNB3 Q8WWL7 1/20 0.40
HDAC4 P56524 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16827316 0.90 LTA4H (0.69) NOTUMLTA4HGSK3BCYP19A1
SCHEMBL722557 0.85 LTA4H (0.64) NOTUMLTA4HHPGDSCHRNA7CHRNA10
SCHEMBL28320605 0.83 LTA4H (0.62) LTA4HHPGDSCHRNA7CHRNA10CHRNA9
SCHEMBL28362996 0.83 LTA4H (0.62) LTA4HHPGDSCHRNA7CHRNA10CHRNA9
SCHEMBL28257875 0.83 LTA4H (0.62) LTA4HHPGDSCHRNA7CHRNA10CHRNA9
SCHEMBL27894650 0.80 LTA4H (0.51) NOTUMLTA4HHPGDSEGLN2CHRNA7
SCHEMBL6126951 0.78 LTA4H (0.46) NOTUMLTA4HHPGDSCHRNA7CHRNA10
SCHEMBL6852126 0.77 LTA4H (0.49) NOTUMLTA4HHPGDSCHRNA7CHRNA10
SCHEMBL17704300 0.77 LTA4H (0.56) LTA4HHPGDSCHRNA7CHRNA10CHRNA9
SCHEMBL5323135 0.76 LTA4H (0.51) NOTUMLTA4HHPGDSCHRNA7CHRNA10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110407763-B Synthesis method of 4- (oxazole-2-yl) benzoic acid 苏州汉德创宏生化科技有限公司 2022-10-14 CN disclosed