Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.62 |
| ▸ | HTR1A | P08908 | 7/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.62 |
| ▸ | DRD3 | P35462 | 6/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | DRD2 | P14416 | 5/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.62 |
| ▸ | DRD1 | P21728 | 5/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.62 |
| ▸ | SLC22A1 | O15245 | 4/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prothipendyl SCHEMBL29393787 | 0.90 | CYP2D6 (0.72) | KMT2ACYP2D6CYP1A2HTR1ACHRM2 | |
| Prothipendyl SCHEMBL145059 | 0.90 | CYP2D6 (0.72) | KMT2ACYP2D6CYP1A2HTR1ACHRM2 | |
| Prothipendyl SCHEMBL5705613 | 0.89 | LMNA (0.72) | KMT2ACYP2D6CYP1A2HTR1ACHRM2 | |
| Prothipendyl SCHEMBL1649843 | 0.89 | CYP2D6 (0.70) | KMT2ACYP2D6CYP1A2HTR1ACHRM2 | |
| Isothipendyl SCHEMBL30017997 | 0.88 | KMT2A (1.00) | KMT2ACYP2D6CYP1A2HTR1ACHRM2 | |
| Isothipendyl SCHEMBL29234 | 0.88 | KMT2A (1.00) | KMT2ACYP2D6CYP1A2HTR1ACHRM2 | |
| Promethazine SCHEMBL6271812 | 0.88 | CYP2D6 (0.76) | KMT2ACYP2D6CYP1A2HTR1ACHRM2 | |
| Isothipendyl SCHEMBL230214 | 0.86 | KMT2A (0.97) | KMT2ACYP2D6CYP1A2HTR1ACHRM2 | |
| Isothipendyl SCHEMBL29500369 | 0.86 | KMT2A (0.97) | KMT2ACYP2D6CYP1A2HTR1ACHRM2 | |
| SCHEMBL26238573 | 0.85 | CYP2D6 (0.64) | KMT2ACYP2D6CYP1A2HTR1ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108025008-A | Compositions and methods for treating substance use disorders, addiction and psychosis | 安比拉神经疗法公司 | 2018-05-11 | — | — | CN | disclosed |