Isothipendyl

Isothipendyl

SCHEMBL29234

CC(CN1c2ccccc2Sc2cccnc21)N(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 1.00
CYP2D6 P10635 5/20 0.72
CHRM2 P08172 5/20 0.72
HTR1A P08908 5/20 0.72
CHRM1 P11229 5/20 0.72
ADRA1A P35348 5/20 0.72
OPRM1 P35372 5/20 0.72
DRD3 P35462 5/20 0.72
KCNH2 Q12809 5/20 0.72
ALDH1A1 P00352 4/20 0.72
ADRA2A P08913 4/20 0.72
DRD1 P21728 4/20 0.72
SLC6A2 P23975 4/20 0.72
SLC6A4 P31645 4/20 0.72
LMNA P02545 3/20 0.72
ALOX15 P16050 3/20 0.72
HSD17B10 Q99714 3/20 0.72
CYP1A2 P05177 3/20 0.72
SLC22A1 O15245 3/20 0.72
PTGS1 P23219 3/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isothipendyl SCHEMBL30017997 1.00 KMT2A (1.00) KMT2ACYP2D6CHRM2HTR1ACHRM1
Isothipendyl SCHEMBL29500369 0.99 KMT2A (0.97) KMT2ACYP2D6CHRM2HTR1ACHRM1
Isothipendyl SCHEMBL230214 0.99 KMT2A (0.97) KMT2ACYP2D6CHRM2HTR1ACHRM1
Isothipendyl SCHEMBL28682222 0.90 KMT2A (0.81) KMT2ACYP2D6CHRM2HTR1ACHRM1
Isothipendyl SCHEMBL19555662 0.90 KMT2A (0.81) KMT2ACYP2D6CHRM2HTR1ACHRM1
Isothipendyl SCHEMBL6035570 0.89 KMT2A (0.79) KMT2ACYP2D6CHRM2HTR1ACHRM1
Promethazine SCHEMBL28860403 0.88 KMT2A (0.77) KMT2ACYP2D6CHRM2HTR1ACHRM1
Isothipendyl SCHEMBL28086235 0.85 KMT2A (0.72) KMT2ACYP2D6CHRM2HTR1ACHRM1
Promethazine SCHEMBL717498 0.84 CYP2D6 (0.94) KMT2ACYP2D6CHRM2HTR1ACHRM1
Promethazine SCHEMBL29362589 0.84 CYP2D6 (0.94) KMT2ACYP2D6CHRM2HTR1ACHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 993 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4704971-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2026-03-11 EP claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
WO-2025082959-A1 A PHENOTHIAZINE-RELATED COMPOUND CONJUGATED TO A PEPTIDE UNIVERSITY OF ULSTER (GB) 2025-04-24 WO claimed
WO-2024229174-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2024-11-07 WO claimed
US-20230255884-A1 FINISHED FIBROUS SRUCTURES AND METHODS OF THEIR USE AND PREPARATION CLEXIO BIOSCIENCES LTD. (IL) 2023-08-17 US claimed
WO-2020222187-A1 FINISHED FIBROUS STRUCTURES AND METHODS OF THEIR USE AND PREPARATION CLEXIO BIOSCIENCES LTD. (IL) 2020-11-05 WO claimed
WO-2020194308-A1 ANTIPRURITIC COMPOSITIONS INNOCAN PHARMA LTD. (IL) 2020-10-01 WO claimed
US-9492541-B2 Phenylepherine containing dosage form SOVEREIGN PHARMACEUTICALS, LLC (US) 2016-11-15 US claimed
US-9179994-B2 Implantable film/mesh composite COVIDIEN LP (US) 2015-11-10 US claimed
US-20150216898-A1 COMPOSITION FOR TREATING PSORIASIS PSORIASIS+CREAMS SWENDEN AB (SE) 2015-08-06 US claimed
US-20050266032-A1 Dosage form containing multiple drugs SOVEREIGN PHARMACEUTICALS, LTD. (US) 2005-12-01 US claimed
CN-1703199-A Aggregate with enhanced deformability comprising at least three amphiphiles for improved transport through a semi-permeable barrier and use of non-invasive drugs in vivo, in particular through the skin IDEA AG (DE) 2005-11-30 CN claimed
WO-2005094832-A1 COMPOSITIONS COMPRISING MELOXICAM BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-10-13 WO claimed
EP-1551370-A1 AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN IDEA AG (DE) 2005-07-13 EP claimed
US-20040105881-A1 Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin IDEA AG (DE) 2004-06-03 US claimed
WO-2004032900-A1 AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN IDEA AG (DE) 2004-04-22 WO claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-0152379-A2 Process for preparing pharmaceutical compositions containing unilamellar liposomes CIBA-GEIGY AG (CH) 1985-08-21 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040105881-A1 Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin CUTA, ABCG2, PIGS KMT2A 4031/4885CYP2D6 632/4885CHRM2 2986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.