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Sugi Predict / Compounds / SCHEMBL2886282

SCHEMBL2886282

SCHEMBL2886282

CCOC(=O)c1nc(Cl)c2c(c1O)c(Cl)c(Cl)n2[C@@H](C)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABRB2 P47870 3/20 0.43
▸ CYP1A2 P05177 3/20 0.43
▸ CYP3A4 P08684 2/20 0.43
▸ GABRA1 P14867 2/20 0.43
▸ CYP11B1 P15538 2/20 0.43
▸ CYP11B2 P19099 2/20 0.43
▸ GABRA2 P47869 2/20 0.43
▸ CYP2C9 P11712 2/20 0.43
▸ CYP2C19 P33261 2/20 0.43
▸ LMNA P02545 2/20 0.43
▸ ABCB11 O95342 1/20 0.43
▸ ALOX12 P18054 2/20 0.38
▸ TP53 P04637 1/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ SLC5A1 P13866 1/20 0.37
▸ SLC5A2 P31639 1/20 0.37
▸ ALDH1A1 P00352 4/20 0.37
▸ MAPT P10636 3/20 0.37
▸ GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2886100 0.88 KDM4E (0.41) GABRB2CYP1A2CYP3A4GABRA1CYP11B1
SCHEMBL2884456 0.81 ALDH1A1 (0.51) GABRB2CYP3A4GABRA2CYP2C9CYP2C19
SCHEMBL2886559 0.80 TSHR (0.47) LMNAALOX12TP53ALDH1A1MAPT
SCHEMBL2884417 0.78 MAPT (0.49) LMNAALOX12TP53RAB9AALDH1A1
SCHEMBL24283837 0.73 CYP1A2 (0.48) GABRB2CYP1A2CYP3A4GABRA1CYP11B1
SCHEMBL21298731 0.73 CYP1A2 (0.48) GABRB2CYP1A2CYP3A4GABRA1CYP11B1
SCHEMBL2885678 0.72 GABRA2 (0.51) GABRB2CYP3A4GABRA2CYP2C9CYP2C19
SCHEMBL21298739 0.72 CYP1A2 (0.50) GABRB2CYP1A2CYP3A4GABRA1CYP11B1
SCHEMBL24283624 0.72 CYP1A2 (0.50) GABRB2CYP1A2CYP3A4GABRA1CYP11B1
SCHEMBL1218002 0.72 EGLN1 (0.54) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3124489-B1 THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN INC (US) 2020-07-15 — — EP disclosed
EP-3124489-A1 THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS Fibrogen, Inc. (US) 2017-02-01 — — EP disclosed
EP-2016078-B1 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN INC (US) 2016-06-15 — — EP disclosed
US-7696223-B2 [(2-bromo-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carbonyl)-amino]-acetic acid; modulates the stability and/or activity of hypoxia inducible factor (HIF) FIBROGEN, INC. (US) 2010-04-13 — — US disclosed
EP-2016078-A2 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN, INC. (US) 2009-01-21 — — EP disclosed
US-20080004309-A1 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF FIBROGEN, INC. 2008-01-03 — — US disclosed
WO-2007115315-A2 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN, INC. (US) 2007-10-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080004309-A1 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF HIF1AN, HIF1A, EGLN2 GABRB2 1903/4885CYP1A2 3345/4885CYP3A4 2477/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.