Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.42 |
| ▸ | EML4 | Q9HC35 | 4/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | ROS1 | P08922 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11031045 | 0.76 | RAD52 (0.55) | FYNSLC2A1TNIKCDK4CDK6 | |
| SCHEMBL3201300 | 0.73 | JAK2 (0.71) | JAK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL29875659 | 0.71 | PTK2 (0.44) | CHEK1FYNSLC2A1TNIKCDK4 | |
| SCHEMBL16332516 | 0.70 | FYN (0.64) | FYNCDK4CCNT1CCND1CDK9 | |
| SCHEMBL21756262 | 0.69 | CHKA (0.55) | FYNCDK4CDK2CCND1CYP1A2 | |
| SCHEMBL30007675 | 0.69 | CHEK1 (0.57) | CHEK1JAK2JAK3SLC2A1CDK4 | |
| SCHEMBL28862907 | 0.69 | CHEK1 (0.57) | CHEK1JAK2JAK3SLC2A1CDK4 | |
| SCHEMBL16332388 | 0.69 | FYN (0.68) | FYNCDK4AURKACCNA2CDK2 | |
| SCHEMBL11909295 | 0.69 | CHEK1 (0.58) | CHEK1JAK2KMT2A | |
| SCHEMBL11030064 | 0.69 | CHEK1 (0.56) | CHEK1SLC2A1CDK4CDK6AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197132-A | HPK1 inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |