Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.49 |
| ▸ | EML4 | Q9HC35 | 4/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | ROS1 | P08922 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28862907 | 1.00 | CHEK1 (0.57) | CHEK1SLC2A1EML4ALKRET | |
| SCHEMBL28862865 | 0.82 | EGFR (0.53) | SLC2A1EML4ALKRETROS1 | |
| SCHEMBL30007126 | 0.82 | EGFR (0.53) | SLC2A1EML4ALKRETROS1 | |
| SCHEMBL30261802 | 0.79 | RET (0.57) | EML4ALKRETROS1FLT3 | |
| SCHEMBL11029146 | 0.74 | SLC2A1 (0.49) | SLC2A1AURKACDK2CDK4CCNA2 | |
| SCHEMBL28891629 | 0.74 | SLC2A1 (0.47) | CHEK1SLC2A1EML4ALKRET | |
| SCHEMBL17690587 | 0.73 | SLC2A1 (0.58) | SLC2A1EML4ALKRETROS1 | |
| SCHEMBL29875589 | 0.73 | RET (0.58) | SLC2A1EML4ALKRETROS1 | |
| SCHEMBL28891673 | 0.73 | RET (0.58) | SLC2A1EML4ALKRETROS1 | |
| SCHEMBL25561947 | 0.72 | FLT3 (0.71) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197132-A | HPK1 inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |