SCHEMBL28863530

SCHEMBL28863530

Cc1nc(Cl)cnc1C(=O)NCC(=O)NC(F)C(F)F

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 9/20 0.35
VEGFA P15692 5/20 0.35
FLT1 P17948 5/20 0.35
EGLN3 Q9H6Z9 4/20 0.35
BACE1 P56817 1/20 0.35
PIK3CD O00329 1/20 0.33
GPR139 Q6DWJ6 4/20 0.33
KMT2A Q03164 1/20 0.33
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PSMB11 A5LHX3 1/20 0.32
PSMA7 O14818 1/20 0.32
PSMB1 P20618 1/20 0.32
PSMA1 P25786 1/20 0.32
PSMA2 P25787 1/20 0.32
PSMA3 P25788 1/20 0.32
PSMA4 P25789 1/20 0.32
PSMB8 P28062 1/20 0.32
PSMB9 P28065 1/20 0.32
PSMA5 P28066 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28863534 0.90 BACE1 (0.35) EGLN1VEGFAFLT1EGLN3BACE1
SCHEMBL28863529 0.84 EGLN1 (0.33) EGLN1VEGFAFLT1EGLN3GPR139
SCHEMBL28863520 0.83 EGLN1 (0.33) EGLN1VEGFAFLT1EGLN3TDP1
SCHEMBL28863525 0.81 NPC1 (0.32) EGLN1L3MBTL1
SCHEMBL23528918 0.79 KDM4E (0.41) EGLN1VEGFAFLT1EGLN3PIK3CD
SCHEMBL29948937 0.79 KDM4E (0.41) EGLN1VEGFAFLT1EGLN3PIK3CD
SCHEMBL31306856 0.72 GRM5 (0.42) BACE1PIK3CDTDP1L3MBTL1ALDH1A1
SCHEMBL23528864 0.69 KDM4E (0.41) EGLN1VEGFAFLT1EGLN3KMT2A
SCHEMBL30937725 0.66 ALDH1A1 (0.38) KMT2ATDP1L3MBTL1ALDH1A1GRM5
SCHEMBL479985 0.66 KMT2A (0.47) KMT2ATDP1L3MBTL1ALDH1A1GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115210221-A Isoxazoline derivatives as pesticides 礼蓝动物保健有限公司 2022-10-18 CN disclosed