SCHEMBL29948937

SCHEMBL29948937

Cc1nc(Cl)cnc1C(=O)NCC(=O)NCC(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.41
GAA P10253 1/20 0.41
LMNA P02545 1/20 0.39
ALDH1A1 P00352 1/20 0.36
EGLN1 Q9GZT9 8/20 0.35
VEGFA P15692 5/20 0.35
FLT1 P17948 5/20 0.35
EGLN3 Q9H6Z9 4/20 0.35
CFTR P13569 2/20 0.33
PIK3CD O00329 1/20 0.33
PIK3CA P42336 1/20 0.32
PIK3CG P48736 1/20 0.32
GABRA5 P31644 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23528918 1.00 KDM4E (0.41) KDM4EGAALMNAALDH1A1EGLN1
SCHEMBL23528864 0.90 KDM4E (0.41) KDM4EGAALMNAALDH1A1EGLN1
SCHEMBL29949030 0.84 LMNA (0.41) KDM4EGAALMNAALDH1A1EGLN1
SCHEMBL23528932 0.84 LMNA (0.41) KDM4EGAALMNAALDH1A1EGLN1
SCHEMBL23528926 0.83 KDM4E (0.40) KDM4EGAALMNAEGLN1VEGFA
SCHEMBL29948802 0.83 KDM4E (0.40) KDM4EGAALMNAALDH1A1EGLN1
SCHEMBL23528868 0.83 KDM4E (0.40) KDM4EGAALMNAALDH1A1EGLN1
SCHEMBL23528930 0.82 KDM4E (0.41) KDM4EGAALMNAALDH1A1EGLN1
SCHEMBL23528927 0.80 KDM4E (0.38) KDM4EGAALMNAEGLN1VEGFA
SCHEMBL28863530 0.79 EGLN1 (0.35) ALDH1A1EGLN1VEGFAFLT1EGLN3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4077286-A1 ISOXAZOLINE DERIVATIVES AS PESTICIDES Elanco Tiergesundheit AG (CH) 2022-10-26 EP disclosed