Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 13/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | F11 | P03951 | 2/20 | 0.44 |
| ▸ | F10 | P00742 | 2/20 | 0.44 |
| ▸ | F9 | P00740 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28593491 | 0.94 | MASP2 (0.59) | MASP2F2CYP3A4PRSS1KCNH2 | |
| SCHEMBL28593489 | 0.94 | MASP2 (0.59) | MASP2F2CYP3A4PRSS1KCNH2 | |
| Trifluoroacetic Acid SCHEMBL23452472 | 0.88 | MASP2 (0.61) | MASP2F2CYP3A4PRSS1F11 | |
| Trifluoroacetic Acid SCHEMBL29880513 | 0.88 | MASP2 (0.61) | MASP2F2CYP3A4PRSS1F11 | |
| Trifluoroacetic Acid SCHEMBL28587649 | 0.88 | MASP2 (0.61) | MASP2F2CYP3A4PRSS1F11 | |
| Trifluoroacetic Acid SCHEMBL28587648 | 0.88 | MASP2 (0.61) | MASP2F2CYP3A4PRSS1F11 | |
| Trifluoroacetic Acid SCHEMBL23454672 | 0.85 | MASP2 (0.60) | MASP2F2CYP3A4PRSS1F11 | |
| Trifluoroacetic Acid SCHEMBL23454676 | 0.85 | MASP2 (0.60) | MASP2F2CYP3A4PRSS1F11 | |
| Trifluoroacetic Acid SCHEMBL30131490 | 0.82 | MASP2 (0.55) | MASP2F2CYP3A4PRSS1KCNH2 | |
| Trifluoroacetic Acid SCHEMBL28579470 | 0.82 | MASP2 (0.49) | MASP2F2CYP3A4PRSS1F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115052862-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2022-09-13 | — | — | CN | disclosed |