Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL14876478 | 0.91 | TP53 (0.48) | TP53PTGS1PTGS2TSHRKMT2A | |
| Lactic Acid SCHEMBL27881883 | 0.84 | TP53 (0.41) | TP53PTGS1PTGS2KMT2A | |
| Lactic Acid SCHEMBL27842030 | 0.82 | TP53 (0.39) | TP53ALDH1A1KMT2A | |
| Acetic Acid SCHEMBL28091100 | 0.79 | FFAR3 (0.41) | TP53PTGS1PTGS2TSHRALDH1A1 | |
| Bicarbonate SCHEMBL177965 | 0.79 | ALDH1A1 (0.37) | TP53TSHRALDH1A1 | |
| Lactic Acid SCHEMBL17492264 | 0.76 | TP53 (0.69) | TP53TSHRALDH1A1PKM | |
| Lactic Acid SCHEMBL6566944 | 0.76 | — | — | |
| Propylene Glycol SCHEMBL8091079 | 0.76 | TDP1 (0.48) | TSHRL3MBTL1 | |
| Lactic Acid SCHEMBL27635887 | 0.76 | — | — | |
| Lactic Acid SCHEMBL7188281 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108909114-A | A kind of carbon dioxide-base composite material and preparation method | 深圳市通产丽星股份有限公司 | 2018-11-30 | — | — | CN | claimed |
| CN-108909114-A | A kind of carbon dioxide-base composite material and preparation method | 深圳市通产丽星股份有限公司 | 2018-11-30 | — | — | CN | disclosed |
| CN-108909114-A | A kind of carbon dioxide-base composite material and preparation method | 深圳市通产丽星股份有限公司 | 2018-11-30 | — | — | CN | disclosed |
| CN-108893082-A | A kind of hot melt adhesive and preparation method thereof | 深圳市通产丽星股份有限公司 | 2018-11-27 | — | — | CN | disclosed |