Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28865776 | 0.81 | KDM4E (0.51) | KDM4EL3MBTL1MAPTSMN1; SMN2GABRA2 | |
| SCHEMBL4218652 | 0.76 | KDM4E (0.71) | KDM4EL3MBTL1MAPTSMN1; SMN2GABRA2 | |
| SCHEMBL4373094 | 0.76 | KDM4E (0.64) | KDM4EL3MBTL1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1492332 | 0.75 | SMN1; SMN2 (0.52) | KDM4EMAPTSMN1; SMN2GABRA2GABRB2 | |
| SCHEMBL187425 | 0.75 | PTPN11 (0.50) | — | |
| Hydrochloric Acid SCHEMBL1492314 | 0.74 | SMN1; SMN2 (0.51) | KDM4EMAPTSMN1; SMN2GABRA2GABRB2 | |
| SCHEMBL5425252 | 0.74 | GABRA2 (0.60) | MAPTSMN1; SMN2GABRA2GABRB2ALDH1A1 | |
| SCHEMBL8059093 | 0.73 | HTT (0.54) | KDM4EMAPTSMN1; SMN2GABRA2GABRB2 | |
| SCHEMBL11937553 | 0.72 | KDM4E (0.56) | KDM4EALDH1A1POLBNPSR1HSD17B10 | |
| SCHEMBL1492389 | 0.71 | KDM4E (0.43) | KDM4EL3MBTL1MAPTSMN1; SMN2GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073470-B | Pyrrolopyrimidinone derivative, and preparation method and application thereof | 南京中瑞药业有限公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-115073470-A | Pyrrolopyrimidinone derivative and preparation method and application thereof | 南京中瑞药业有限公司 | 2022-09-20 | — | — | CN | disclosed |