Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3063647 | 0.77 | KDM4E (0.67) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL4531554 | 0.76 | ALDH1A1 (0.48) | KDM4EPDE4BALDH1A1GRM6HPGD | |
| SCHEMBL28865786 | 0.76 | KDM4E (0.77) | KDM4EALDH1A1HSD17B10NPSR1POLB | |
| SCHEMBL4373094 | 0.75 | KDM4E (0.64) | KDM4EALDH1A1HSD17B10POLBHPGD | |
| SCHEMBL28676791 | 0.72 | PDE4B (0.51) | KDM4EPDE4BALDH1A1NPSR1POLB | |
| SCHEMBL4530631 | 0.72 | L3MBTL1 (0.45) | KDM4EPDE4BALDH1A1NPSR1POLB | |
| SCHEMBL30504026 | 0.69 | GABRA2 (0.61) | PDE4BALDH1A1GAAGABRA2GABRB2 | |
| SCHEMBL21314958 | 0.69 | GABRA2 (0.61) | PDE4BALDH1A1GAAGABRA2GABRB2 | |
| SCHEMBL28685593 | 0.69 | PDE4B (0.50) | PDE4BALDH1A1GABRA2GABRB2 | |
| SCHEMBL30350059 | 0.69 | CYP11B2 (0.52) | KDM4EPDE4BALDH1A1NPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090192138-A1 | COMPOUNDS | BAESCHLIN DANIEL KASPAR | 2009-07-30 | — | — | US | disclosed |
| EP-1966215-A1 | CONDENSED HETEROCYCLIC COMPOUNDS USEFUL AS DPP-IV INHIBITORS | Novartis AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071738-A1 | CONDENSED HETEROCYCLIC COMPOUNDS USEFUL AS DPP-IV INHIBITORS | NOVARTIS AG (CH) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192138-A1 | COMPOUNDS | DPP4, DPP3, DPP8 | KDM4E 766/4885PDE4B 32/4885ALDH1A1 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.