SCHEMBL2886828

SCHEMBL2886828

CCOC(=O)c1c(Br)c(-c2ccc(F)cc2)n(-c2ccc(OC)cc2)c1CNC(C(=O)OCC)C(=O)OC(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.37
MAPT P10636 3/20 0.37
LMNA P02545 2/20 0.36
KMT2A Q03164 1/20 0.36
PDE4D Q08499 1/20 0.36
POLB P06746 2/20 0.35
GAA P10253 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
CHRNA7 P36544 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34
GRM6 O15303 2/20 0.34
PRKCZ Q05513 1/20 0.34
P2RX3 P56373 1/20 0.34
NPSR1 Q6W5P4 1/20 0.33
GABRA2 P47869 1/20 0.33
GABRB2 P47870 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2886135 0.96 GRM6 (0.36) ALDH1A1MAPTLMNAKMT2APOLB
SCHEMBL2887868 0.92 ALDH1A1 (0.38) ALDH1A1MAPTLMNAKMT2APOLB
SCHEMBL2880839 0.85 MAPK14 (0.34) ALDH1A1MAPTLMNAKMT2APOLB
SCHEMBL2886567 0.84 GABRA2 (0.38) ALDH1A1MAPTLMNAKMT2APOLB
SCHEMBL2887393 0.81 MAPK14 (0.34) ALDH1A1MAPTLMNAKMT2APOLB
SCHEMBL2880662 0.81 PDE4D (0.44) ALDH1A1MAPTLMNAKMT2APDE4D
SCHEMBL2880654 0.80 TP53 (0.40) ALDH1A1MAPTLMNAKMT2APOLB
SCHEMBL2882141 0.78 ALDH1A1 (0.36) ALDH1A1MAPTLMNAKMT2APDE4D
SCHEMBL2880589 0.76 MAPT (0.41) ALDH1A1MAPTLMNAPOLBPRKCZ
SCHEMBL2885360 0.76 GRM6 (0.46) ALDH1A1MAPTLMNAKMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115198551-A Method for producing bleached wood fibre material 巴斯夫欧洲公司 2022-10-18 CN disclosed
EP-3124489-B1 THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN INC (US) 2020-07-15 EP disclosed
EP-3124489-A1 THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS Fibrogen, Inc. (US) 2017-02-01 EP disclosed
EP-2016078-B1 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN INC (US) 2016-06-15 EP disclosed
US-20100282505-A1 Method for producing conductive film and light-sensitive material for conductive film production FUJIFILM CORPORATION (JP) 2010-11-11 US disclosed
US-7749686-B2 Method for producing conductive film and light-sensitive material for conductive film production FUJIFILM CORPORATION (JP) 2010-07-06 US disclosed
US-7696223-B2 [(2-bromo-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carbonyl)-amino]-acetic acid; modulates the stability and/or activity of hypoxia inducible factor (HIF) FIBROGEN, INC. (US) 2010-04-13 US disclosed
CN-101631793-A Electroluminescent metal complexes of benzotriazoles BASF SE 2010-01-20 CN disclosed
EP-2016078-A2 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN, INC. (US) 2009-01-21 EP disclosed
US-20080004309-A1 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF FIBROGEN, INC. 2008-01-03 US disclosed
US-4578345-A ACCELERATED BLEACHING PROCESS;NON-TOXIC, ENVIRONMENTALLY SAFE FUJI PHOTO FILM CO., LTD. (JP) 1986-03-25 US disclosed
US-4574115-A MULTILAYER, METAL GRAINS FUJI PHOTO FILM CO., LTD. (JP) 1986-03-04 US disclosed
US-4558000-A POLYTRIAZINES TO PREVENT COLOR BALANCE DETERIORATION DUE TO VARIATION IN POTASSIUM BROMIDE CONCENTRATION IN DEVELOPER FUJI PHOTO FILM CO., LTD. (JP) 1985-12-10 US disclosed
US-4554242-A Method for processing color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1985-11-19 US disclosed
US-4546070-A CONTAINING A MERCAPTO, DISULFIDE, THIAZOLIDINE OR ISOTHIOUREA BLEACH ACCELERATOR AND A 2,5-DISULFIDE-1,3,4-THIADIZOLE COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1985-10-08 US disclosed
EP-0146087-A2 Method for processing color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1985-06-26 EP disclosed
US-4524129-A ADDING A 5-THIOTETRAZOLE DERIVATIVE PROMOTER TO THE BLEACHING AND/OR FIXING BATH; NONTOXIC FUJI PHOTO FILM CO., LTD. (JP) 1985-06-18 US disclosed
EP-0119851-A2 Colour reversal light-sensitive photographic material FUJI PHOTO FILM CO., LTD. (JP) 1984-09-26 EP disclosed
EP-0115304-A2 Silver halide multi-layered color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1984-08-08 EP disclosed
US-4276374-A Silver halide photographic emulsion with thioether sensitizer FUJI PHOTO FILM CO., LTD. (JP) 1981-06-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080004309-A1 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF HIF1AN, HIF1A, EGLN2 ALDH1A1 1047/4885MAPT 2965/4885LMNA 4255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.