Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ABAT | P80404 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14647889 | 0.81 | MEN1 (0.65) | ALDH1A1LMNAMEN1KMT2AHDAC6 | |
| SCHEMBL8135278 | 0.79 | KLKB1 (0.52) | HTTLMNATPSAB1LOXL2ABAT | |
| SCHEMBL27633225 | 0.76 | AOC2 (0.58) | TPSAB1LOXL2ABATHDAC3HDAC6 | |
| SCHEMBL1189878 | 0.76 | CA12 (0.59) | HTTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL13939687 | 0.76 | TPSAB1 (0.75) | ALDH1A1TPSAB1LOXL2 | |
| SCHEMBL27687066 | 0.75 | TPSAB1 (0.52) | HTTALDH1A1TPSAB1LOXL2MEN1 | |
| SCHEMBL2584802 | 0.74 | HTT (0.50) | HTTALDH1A1TPSAB1LOXL2MEN1 | |
| SCHEMBL27966406 | 0.73 | GAA (0.67) | HTTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2584667 | 0.71 | TPSAB1 (0.49) | TPSAB1LOXL2MAPT | |
| SCHEMBL11079658 | 0.71 | KDM4E (0.52) | TPSAB1LOXL2ABATHDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109020846-A | O- replaces tyrosine Bcl-2 protein inhibitor and preparation method and application | 山东大学 | 2018-12-18 | — | — | CN | disclosed |