Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 6/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21772349 | 0.98 | TSHR (0.69) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL16573 | 0.98 | — | — | |
| Dimethylamine SCHEMBL1033277 | 0.96 | TSHR (0.62) | TSHRTHRBALDH1A1TDP1POLB | |
| Hydrochloric Acid SCHEMBL8572537 | 0.95 | TSHR (0.67) | TSHRTHRBALDH1A1TDP1POLB | |
| Hydrochloric Acid SCHEMBL31358617 | 0.95 | TSHR (0.67) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL1514196 | 0.95 | TSHR (0.67) | TSHRTHRBALDH1A1TDP1POLB | |
| Lithium SCHEMBL30566726 | 0.95 | TSHR (0.67) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL6879356 | 0.95 | TSHR (0.67) | TSHRTHRBALDH1A1TDP1POLB | |
| Hydrogen Sulfide SCHEMBL6879353 | 0.95 | TSHR (0.67) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL31029924 | 0.95 | TSHR (0.67) | TSHRTHRBALDH1A1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109312036-A | Hydrogenated block copolymer, vibration-absorptive material, acoustic material, intermediate film for laminated glasses, seal rubber, sole material, flooring material, laminated body and laminated glass | 株式会社可乐丽 | 2019-02-05 | — | — | CN | disclosed |
| CN-109071860-A | Expanded moldings, seal rubber, the complex of seal rubber and panel, the method that increases sound transmission loss | 株式会社可乐丽 | 2018-12-21 | — | — | CN | disclosed |