Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | POLB | P06746 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4141035 | 0.80 | PTPN1 (0.51) | PTPN1PTPN2PTPN6KDM4EPOLB | |
| SCHEMBL8673355 | 0.80 | CSNK2A1 (0.59) | KDM4EPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL1673212 | 0.79 | PTPN1 (0.54) | PTPN1PTPN2PTPN6KDM4EPOLB | |
| SCHEMBL27596775 | 0.78 | PTPN1 (0.47) | PTPN1PTPN2PTPN6KDM4EPOLB | |
| SCHEMBL18920538 | 0.77 | POLB (0.56) | PTPN1PTPN2PTPN6KDM4EPOLB | |
| SCHEMBL3229733 | 0.75 | HDAC7 (0.70) | PTPN1KDM4EPOLBALDH1A1L3MBTL1 | |
| SCHEMBL14003530 | 0.74 | ALDH1A1 (0.47) | KDM4EPOLBALDH1A1L3MBTL1MEN1 | |
| SCHEMBL6514220 | 0.74 | KDM4E (0.47) | KDM4EPOLBALDH1A1L3MBTL1MEN1 | |
| SCHEMBL13912480 | 0.74 | KDM4E (0.73) | KDM4EPOLBALDH1A1L3MBTL1MEN1 | |
| SCHEMBL6963436 | 0.73 | PTPN1 (0.49) | PTPN1PTPN2PTPN6KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109293606-A | 2, 5-disubstituted furan derivative and application thereof as SIRT protein inhibitor in preparation of medicines | 西华大学 | 2019-02-01 | — | — | CN | disclosed |