Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.70 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | HNF4A | P41235 | 2/20 | 0.47 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6498971 | 0.90 | HDAC7 (0.57) | HDAC7ALDH1A1HSD17B10CSNK2A1POLB | |
| SCHEMBL31241243 | 0.89 | HDAC7 (0.57) | HDAC7ALDH1A1KDM4EHSD17B10CSNK2A1 | |
| Diethylamine SCHEMBL7352284 | 0.89 | HDAC7 (0.61) | HDAC7PTGDR2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1515691 | 0.87 | HDAC7 (0.68) | HDAC7PTGDR2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8673355 | 0.86 | CSNK2A1 (0.59) | HDAC7ALDH1A1KDM4ECSNK2A1POLB | |
| SCHEMBL11154359 | 0.85 | ALDH1A1 (0.55) | HDAC7ALDH1A1KDM4ECSNK2A1POLB | |
| SCHEMBL31541702 | 0.85 | HDAC7 (0.66) | HDAC7PTGDR2L3MBTL1 | |
| SCHEMBL6514862 | 0.85 | HDAC7 (0.66) | HDAC7PTGDR2L3MBTL1 | |
| SCHEMBL9683573 | 0.85 | HSD17B10 (0.58) | HDAC7ALDH1A1HSD17B10CSNK2A1POLB | |
| SCHEMBL11491969 | 0.85 | HDAC7 (0.51) | HDAC7ALDH1A1KDM4EHSD17B10CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4276193-A | MAGNESIUM DIHALIDE CARRIER, CATALYST COMPRISING AN ELECTRON DONOR, TITANIUM TETRACHLORIDE REDUCED WITH AN ORGANOALUMINUM HALIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1981-06-30 | — | — | US | claimed |
| WO-2022133551-A1 | HISTONE DEACETYLASE INHIBITORS | THE UNIVERSITY OF QUEENSLAND (AU) | 2022-06-30 | — | — | WO | disclosed |
| CN-110862368-B | Photocatalytic oxidation synthesis method of benzocoumarin compound | 浙江工业大学 | 2021-06-15 | — | — | CN | disclosed |
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| CN-110862368-A | Photocatalytic oxidation synthesis method of benzocoumarin compound | 浙江工业大学 | 2020-03-06 | — | — | CN | disclosed |
| EP-2906553-B1 | OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-06-26 | — | — | EP | disclosed |
| EP-3029026-B1 | NOVEL BIPHENYL DERIVATIVE AND METHOD FOR PREPARING SAME | DONG A ST CO LTD (KR) | 2018-12-05 | — | — | EP | disclosed |
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-05-24 | — | — | US | disclosed |
| WO-2018081285-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |
| CN-104703980-B | Belong to the orexin receptor antagonists of [adjacent double (miscellaneous) aryl] [base of 2 (double (miscellaneous) aryl) pyrrolidines 1] ketone derivatives | 埃科特莱茵药品有限公司 | 2017-09-22 | — | — | CN | disclosed |
| EP-0873123-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-10-28 | — | — | EP | disclosed |
| US-5748271-A | Electroluminescent device having electroluminescent compound and liquid crystalline compound | U.S. PHILIPS CORPORATION (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0787419-A1 | ELECTROLUMINESCENT DEVICE | Koninklijke Philips Electronics N.V. (NL) | 1997-08-06 | — | — | EP | disclosed |
| WO-1997017070-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1997-05-15 | — | — | WO | disclosed |
| WO-1997007654-A1 | ELECTROLUMINESCENT DEVICE | PHILIPS ELECTRONICS N.V. (NL) | 1997-02-27 | — | — | WO | disclosed |
| EP-0008764-B1 | PROCESS FOR THE PREPARATION OF A CATALYST ON A SOLID CARRIER AND ITS USE IN THE POLYMERISATION OF PROPYLENE | BAYER AG (DE) | 1982-09-22 | — | — | EP | disclosed |
| US-4339560-A | Process for polymerizing olefins | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| US-4276193-A | MAGNESIUM DIHALIDE CARRIER, CATALYST COMPRISING AN ELECTRON DONOR, TITANIUM TETRACHLORIDE REDUCED WITH AN ORGANOALUMINUM HALIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1981-06-30 | — | — | US | disclosed |
| EP-0008764-A2 | Process for the preparation of a catalyst on a solid carrier and its use in the polymerisation of propylene | BAYER AG (DE) | 1980-03-19 | — | — | EP | disclosed |
| US-3932430-A | Substituted indeno, naphtho and cyclohepta pyrazoles | SANDOZ, INC. (US) | 1976-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | NR1H4, FXR1, SLC10A1 | HDAC7 545/4885PTGDR2 941/4885ALDH1A1 2185/4885 |
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | NR1H4, FXR1, SLC10A1 | HDAC7 545/4885PTGDR2 941/4885ALDH1A1 2185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.