Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 7/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.38 |
| ▸ | CHRNA10 | Q9GZZ6 | 5/20 | 0.38 |
| ▸ | CHRNA9 | Q9UGM1 | 5/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL5701064 | 0.81 | ALDH1A1 (0.82) | ALDH1A1TSHRPOLBTP53TDP1 | |
| Styrene SCHEMBL7110157 | 0.81 | ALDH1A1 (0.82) | ALDH1A1TSHRPOLBTP53TDP1 | |
| Styrene SCHEMBL7737395 | 0.81 | ALDH1A1 (0.82) | ALDH1A1TSHRPOLBTP53TDP1 | |
| Styrene SCHEMBL8853396 | 0.77 | ALDH1A1 (0.74) | ALDH1A1TSHRPOLBTP53TDP1 | |
| Styrene SCHEMBL29116192 | 0.77 | ALDH1A1 (0.74) | ALDH1A1TSHRPOLBTP53TDP1 | |
| Styrene SCHEMBL28600228 | 0.77 | ALDH1A1 (0.74) | ALDH1A1TSHRPOLBTP53TDP1 | |
| Styrene SCHEMBL9299099 | 0.75 | TSHR (0.64) | ALDH1A1TSHRPOLBSMN1; SMN2TP53 | |
| Styrene SCHEMBL27739152 | 0.74 | ALDH1A1 (0.78) | ALDH1A1TSHRCYP3A4TP53TDP1 | |
| Styrene SCHEMBL5344586 | 0.73 | ALDH1A1 (0.88) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| Styrene SCHEMBL28366334 | 0.73 | ALDH1A1 (0.88) | ALDH1A1TSHRMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109401731-A | A kind of amphipathy macromolecule load nano-fluid and preparation method thereof | 中国矿业大学 | 2019-03-01 | — | — | CN | claimed |
| CN-109401731-A | A kind of amphipathy macromolecule load nano-fluid and preparation method thereof | 中国矿业大学 | 2019-03-01 | — | — | CN | disclosed |