Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.33 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28870639 | 1.00 | ROCK2 (0.33) | ROCK2ROCK1PKN2RPS6KA5LRRK2 | |
| SCHEMBL28284263 | 0.79 | SLC6A2 (0.31) | — | |
| SCHEMBL25996380 | 0.77 | RPS6KA3 (0.45) | RPS6KA3 | |
| SCHEMBL28282710 | 0.77 | MAPT (0.31) | — | |
| SCHEMBL28284287 | 0.77 | GAA (0.37) | — | |
| SCHEMBL28282634 | 0.77 | MAPT (0.31) | — | |
| SCHEMBL28284286 | 0.77 | GAA (0.37) | — | |
| SCHEMBL28282633 | 0.77 | MAPT (0.31) | — | |
| SCHEMBL26030475 | 0.74 | RPS6KA3 (0.45) | RPS6KA3 | |
| SCHEMBL25493980 | 0.71 | TSHR (0.41) | TP53HTTTSHRRPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109415358-A | 6-aminopyridin-3-ylthiazoles as ROR gamma t modulators | 詹森药业有限公司 | 2019-03-01 | — | — | CN | disclosed |