Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | CDKL3 | Q8IVW4 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28871293 | 0.95 | PRKAB2 (0.45) | MRGPRX4MAPK10FLT4PRKD3MAPK9 | |
| SCHEMBL28871315 | 0.88 | MAPK1 (0.48) | MRGPRX4MAPK10FLT4PRKD3MAPK9 | |
| SCHEMBL29968039 | 0.85 | KDR (0.39) | FLT4MAPK8FLT3KITCDC7 | |
| SCHEMBL29968363 | 0.83 | MAPK10 (0.54) | MRGPRX4MAPK10FLT4PRKD3MAPK9 | |
| SCHEMBL28957360 | 0.83 | NR1H4 (0.53) | MRGPRX4MAPK10FLT4PRKD3MAPK9 | |
| SCHEMBL29968183 | 0.83 | NR1H4 (0.53) | MRGPRX4MAPK10FLT4PRKD3MAPK9 | |
| SCHEMBL28871255 | 0.83 | MAPK10 (0.54) | MRGPRX4MAPK10FLT4PRKD3MAPK9 | |
| SCHEMBL28871262 | 0.83 | MAPK10 (0.45) | MAPK10FLT4PRKD3MAPK9CDKL3 | |
| SCHEMBL29967878 | 0.83 | MAPK10 (0.45) | MAPK10FLT4PRKD3MAPK9CDKL3 | |
| SCHEMBL29967968 | 0.82 | MAPK10 (0.44) | MAPK10FLT4PRKD3MAPK9CDKL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260165-A | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-11-01 | — | — | CN | disclosed |