Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22210862 | 1.00 | RIPK1 (0.39) | RIPK1PIK3R1PIK3CADPP4GPR119 | |
| SCHEMBL29966680 | 1.00 | RIPK1 (0.39) | RIPK1PIK3R1PIK3CADPP4GPR119 | |
| SCHEMBL30339166 | 0.91 | RIPK1 (0.34) | RIPK1PIK3R1PIK3CADPP4GPR119 | |
| SCHEMBL18921502 | 0.85 | RIPK1 (0.39) | RIPK1ALDH1A1ABL1 | |
| SCHEMBL30338931 | 0.84 | RIPK1 (0.42) | RIPK1PIK3R1PIK3CAGPR119 | |
| SCHEMBL29048238 | 0.84 | RIPK1 (0.42) | RIPK1PIK3R1PIK3CAGPR119 | |
| SCHEMBL30338821 | 0.84 | RIPK1 (0.42) | RIPK1PIK3R1PIK3CAGPR119 | |
| SCHEMBL29048328 | 0.84 | RIPK1 (0.42) | RIPK1PIK3R1PIK3CAGPR119 | |
| SCHEMBL18921383 | 0.83 | RIPK1 (0.41) | RIPK1ABL1 | |
| SCHEMBL22608904 | 0.82 | NTRK1 (0.42) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| CN-108602809-B | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1(RIPK 1) | 戴纳立制药公司 | 2022-09-30 | — | — | CN | disclosed |