Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29966680 | 0.91 | RIPK1 (0.39) | RIPK1PIK3R1PIK3CAGPR119DPP4 | |
| SCHEMBL22210862 | 0.91 | RIPK1 (0.39) | RIPK1PIK3R1PIK3CAGPR119DPP4 | |
| SCHEMBL28873169 | 0.91 | RIPK1 (0.39) | RIPK1PIK3R1PIK3CAGPR119DPP4 | |
| SCHEMBL30339051 | 0.85 | NPSR1 (0.32) | — | |
| SCHEMBL30339115 | 0.83 | DGAT1 (0.35) | GPR119 | |
| Trifluoroacetic Acid SCHEMBL30338762 | 0.81 | NTRK1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL30338587 | 0.81 | RIPK1 (0.38) | RIPK1DPP4 | |
| SCHEMBL30338978 | 0.79 | GPR119 (0.39) | RIPK1GPR119 | |
| SCHEMBL30339304 | 0.79 | GPR119 (0.34) | RIPK1GPR119 | |
| SCHEMBL30339114 | 0.78 | LMNA (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |