Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20580237 | 1.00 | RIPK1 (0.41) | RIPK1KIF11CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL22210929 | 0.83 | POLB (0.45) | RIPK1KIF11CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL22232765 | 0.82 | RIPK1 (0.43) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL18921305 | 0.82 | RIPK1 (0.43) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL20580690 | 0.82 | RIPK1 (0.50) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL20580272 | 0.81 | RIPK1 (0.46) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL18921351 | 0.81 | RIPK1 (0.46) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL18921500 | 0.81 | RIPK1 (0.46) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL26089736 | 0.80 | RIPK1 (0.41) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL20580293 | 0.79 | RIPK1 (0.58) | RIPK1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602809-B | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1(RIPK 1) | 戴纳立制药公司 | 2022-09-30 | — | — | CN | disclosed |