SCHEMBL28874822

SCHEMBL28874822

N#Cc1c(Cl)c2ccc(C(F)(F)F)nc2n(-c2ccccc2Cl)c1=O

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAT2A P31153 15/20 0.59
KDM4E B2RXH2 2/20 0.45
ALDH1A1 P00352 2/20 0.45
GLA P06280 2/20 0.45
GAA P10253 2/20 0.45
S1PR4 O95977 1/20 0.45
S1PR1 P21453 1/20 0.45
MEN1 O00255 1/20 0.36
HPGD P15428 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30038981 1.00 MAT2A (0.59) MAT2AKDM4EALDH1A1GLAGAA
SCHEMBL30040326 0.89 MAT2A (0.57) MAT2AKDM4EALDH1A1GLAGAA
SCHEMBL28874834 0.89 MAT2A (0.57) MAT2AKDM4EALDH1A1GLAGAA
SCHEMBL28874802 0.87 MAT2A (0.63) MAT2AKDM4EALDH1A1GLAGAA
SCHEMBL30039373 0.87 MAT2A (0.63) MAT2AKDM4EALDH1A1GLAGAA
SCHEMBL29417519 0.86 MAT2A (0.45) MAT2AKDM4EALDH1A1GLAGAA
SCHEMBL28978825 0.86 MAT2A (0.45) MAT2AKDM4EALDH1A1GLAGAA
SCHEMBL28978819 0.83 MAT2A (0.45) MAT2AKDM4EALDH1A1MEN1KMT2A
SCHEMBL29417550 0.82 KDM4E (0.42) MAT2AKDM4EALDH1A1GLAGAA
SCHEMBL28978822 0.82 KDM4E (0.42) MAT2AKDM4EALDH1A1GLAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115260187-A Pyridone compounds and uses thereof 武汉人福创新药物研发中心有限公司 2022-11-01 CN disclosed