Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.61 |
| ▸ | JAK3 | P52333 | 3/20 | 0.61 |
| ▸ | JAK1 | P23458 | 2/20 | 0.61 |
| ▸ | TYK2 | P29597 | 2/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28876012 | 0.91 | JAK3 (0.63) | JAK2JAK3JAK1TYK2SLC6A3 | |
| SCHEMBL28875983 | 0.90 | JAK2 (0.62) | JAK2JAK3JAK1TYK2SLC6A3 | |
| SCHEMBL28556663 | 0.83 | JAK2 (0.68) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL28876023 | 0.82 | JAK1 (0.61) | JAK2JAK3JAK1 | |
| Morpholine SCHEMBL28330189 | 0.81 | JAK2 (0.70) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL28876005 | 0.81 | JAK2 (0.64) | JAK2JAK3JAK1TYK2SLC6A3 | |
| SCHEMBL28385501 | 0.78 | EGFR (0.48) | — | |
| SCHEMBL29037811 | 0.77 | DYRK2 (0.49) | — | |
| SCHEMBL29813742 | 0.76 | JAK2 (1.00) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL28875992 | 0.76 | JAK2 (1.00) | JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-B | Substituted phenyl pyrimidine derivative as JAK kinase inhibitor or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |