Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.71 |
| ▸ | JAK3 | P52333 | 11/20 | 0.71 |
| ▸ | JAK1 | P23458 | 10/20 | 0.71 |
| ▸ | PLK4 | O00444 | 2/20 | 0.65 |
| ▸ | TYK2 | P29597 | 4/20 | 0.63 |
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.52 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29813539 | 1.00 | JAK2 (0.71) | JAK2JAK3JAK1PLK4TYK2 | |
| SCHEMBL28875981 | 0.91 | JAK3 (0.72) | JAK2JAK3JAK1PLK4TYK2 | |
| SCHEMBL29813737 | 0.91 | JAK3 (0.72) | JAK2JAK3JAK1PLK4TYK2 | |
| SCHEMBL13859449 | 0.89 | JAK3 (0.77) | JAK2JAK3JAK1PLK4TYK2 | |
| SCHEMBL28876015 | 0.88 | JAK3 (0.56) | JAK2JAK3JAK1PLK4TYK2 | |
| Morpholine SCHEMBL28328992 | 0.86 | JAK3 (0.53) | JAK2JAK3JAK1PLK4TYK2 | |
| SCHEMBL29813697 | 0.86 | JAK3 (0.84) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL28876030 | 0.86 | JAK3 (0.84) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL30051906 | 0.83 | JAK2 (1.00) | JAK2JAK3JAK1PLK4TYK2 | |
| SCHEMBL3622218 | 0.83 | JAK2 (1.00) | JAK2JAK3JAK1PLK4TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-B | Substituted phenyl pyrimidine derivative as JAK kinase inhibitor or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |