Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.53 |
| ▸ | JAK1 | P23458 | 9/20 | 0.53 |
| ▸ | JAK2 | O60674 | 8/20 | 0.53 |
| ▸ | TYK2 | P29597 | 6/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL28328995 | 0.92 | PLK4 (0.53) | JAK3JAK1JAK2TYK2PLK4 | |
| SCHEMBL28876010 | 0.86 | JAK2 (0.71) | JAK3JAK1JAK2TYK2PLK4 | |
| SCHEMBL29813539 | 0.86 | JAK2 (0.71) | JAK3JAK1JAK2TYK2PLK4 | |
| Morpholine SCHEMBL28329001 | 0.86 | JAK3 (0.66) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28876015 | 0.83 | JAK3 (0.56) | JAK3JAK1JAK2TYK2PLK4 | |
| Morpholine SCHEMBL28328996 | 0.78 | JAK3 (0.72) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28328991 | 0.77 | JAK3 (0.48) | JAK3JAK1JAK2TYK2PLK4 | |
| SCHEMBL28875981 | 0.76 | JAK3 (0.72) | JAK3JAK1JAK2TYK2PLK4 | |
| SCHEMBL29813737 | 0.76 | JAK3 (0.72) | JAK3JAK1JAK2TYK2PLK4 | |
| SCHEMBL13859449 | 0.75 | JAK3 (0.77) | JAK3JAK1JAK2TYK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-A | Replace class phenyl pyrimidine derivative as jak kinase inhibitor or its pharmaceutical salt, Preparation method and use | 中国药科大学 | 2019-10-15 | — | — | CN | claimed |
| CN-110330484-A | Replace class phenyl pyrimidine derivative as jak kinase inhibitor or its pharmaceutical salt, Preparation method and use | 中国药科大学 | 2019-10-15 | — | — | CN | disclosed |