Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | MGMT | P16455 | 8/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | DHFR | P00374 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29974026 | 1.00 | CCNA2 (0.48) | CCNA2CDK2CCNA1MGMTKMT2A | |
| SCHEMBL27952825 | 0.92 | CDK2 (0.55) | CCNA2CDK2CCNA1MGMTKMT2A | |
| SCHEMBL28279035 | 0.84 | CCNA2 (0.38) | CCNA2CDK2CCNA1MGMTKMT2A | |
| SCHEMBL27861816 | 0.83 | CCNA2 (0.37) | CCNA2CDK2CCNA1KMT2AALDH1A1 | |
| SCHEMBL9640554 | 0.78 | MGMT (0.49) | CCNA2CDK2CCNA1MGMTKMT2A | |
| SCHEMBL6280645 | 0.75 | MGMT (0.41) | CCNA2CDK2CCNA1MGMTKMT2A | |
| SCHEMBL29974285 | 0.72 | HRH2 (0.42) | CCNA2CDK2CCNA1MGMTKMT2A | |
| SCHEMBL3955746 | 0.71 | MGMT (0.44) | CCNA2CDK2CCNA1MGMTDHFR | |
| SCHEMBL8559943 | 0.70 | MEN1 (0.34) | CCNA2CDK2CCNA1MGMTKMT2A | |
| SCHEMBL31672776 | 0.70 | ALDH1A1 (0.41) | KMT2AALDH1A1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115141202-A | Pyrimidopyrazinone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-04 | — | — | CN | disclosed |