Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20993621 | 0.82 | KDM4E (0.51) | KDM4EMAPK1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL1319808 | 0.77 | KDM4E (0.50) | KDM4EMAPK1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL9448465 | 0.77 | KMT2A (0.67) | KDM4EMAPK1NPC1MITFTHRB | |
| SCHEMBL24792668 | 0.76 | KDM4E (0.52) | KDM4EMAPK1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL31716150 | 0.75 | KDM4E (0.47) | KDM4EALDH1A1HTTKMT2AMEN1 | |
| SCHEMBL7136119 | 0.75 | ALDH1A1 (0.56) | KDM4EMAPK1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL6119473 | 0.74 | KDM4E (0.65) | KDM4EMAPK1RAB9AALDH1A1MAPT | |
| SCHEMBL874173 | 0.74 | KDM4E (0.77) | KDM4EMAPK1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL28783724 | 0.73 | KDM4E (0.45) | KDM4EMAPK1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL20679550 | 0.73 | SMN1; SMN2 (0.66) | KDM4ENPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260164-B | Preparation method, structural composition and application of novel 4 (3H) -quinazolinone analogue in antitumor drugs | 杭州星鳌生物科技有限公司 | 2024-03-26 | — | — | CN | disclosed |
| WO-2022233253-A1 | METHOD FOR PREPARING NEW 4(3H)-QUINAZOLINONE ANALOG, STRUCTURAL COMPOSITION THEREOF, AND USE THEREOF IN ANTITUMOR DRUGS | 杭州星鳌生物科技有限公司 | 2022-11-10 | — | — | WO | disclosed |
| CN-115260164-A | Preparation method and structural composition of novel 4 (3H) -quinazolinone analogue and application of analogue in antitumor drugs | 杭州星鳌生物科技有限公司 | 2022-11-01 | — | — | CN | disclosed |