SCHEMBL31716150

SCHEMBL31716150

COc1cc(NC(=O)Cc2cn[nH]c2)c(C(N)=O)cc1OC

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.47
▸ ALPL P05186 1/20 0.44
▸ MEN1 O00255 3/20 0.43
▸ KMT2A Q03164 3/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ POLB P06746 2/20 0.43
▸ HTT P42858 1/20 0.43
▸ MAPK10 P53779 1/20 0.43
▸ AAK1 Q2M2I8 1/20 0.43
▸ GAA P10253 3/20 0.42
▸ NOS2 P35228 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ GFER P55789 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ EPHX2 P34913 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31716322 0.79 SIRT2 (0.49) KDM4EALDH1A1MAPK10GAANOS2
SCHEMBL28878057 0.75 KDM4E (0.53) KDM4EMEN1KMT2AALDH1A1POLB
SCHEMBL7481213 0.74 KDM4E (0.61) KDM4EMEN1KMT2AALDH1A1POLB
SCHEMBL20993621 0.73 KDM4E (0.51) KDM4EMEN1KMT2AALDH1A1POLB
SCHEMBL7482211 0.72 KDM4E (0.59) KDM4EMEN1KMT2AALDH1A1POLB
SCHEMBL31716585 0.71 KDM4E (0.41) KDM4EMEN1KMT2AALDH1A1POLB
SCHEMBL31716884 0.71 CYP11B2 (0.41) KDM4EMEN1KMT2AALDH1A1HTT
SCHEMBL31716033 0.71 GAA (0.47) KDM4EALPLMEN1KMT2AALDH1A1
SCHEMBL8637152 0.70 GAA (0.64) KDM4EMEN1KMT2APOLBHTT
SCHEMBL25237063 0.68 NOS2 (0.56) NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025227032-A1 METHODS FOR DEGRADATION OF CYCLIN K AND INHIBITION OF CYCLIN DEPENDENT KINASES REMIX THERAPEUTICS INC. (US) 2025-10-30 — — WO disclosed
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