Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1437221 | 0.89 | NOS3 (0.48) | NOS3NOS2SIRT3TDP1LIMK1 | |
| SCHEMBL30631992 | 0.89 | NOS3 (0.48) | NOS3NOS2SIRT3TDP1LIMK1 | |
| Water SCHEMBL21833988 | 0.88 | NOS3 (0.47) | NOS3NOS2SIRT3TDP1LIMK1 | |
| Hydrochloric Acid SCHEMBL16741076 | 0.88 | NOS3 (0.47) | NOS3NOS2SIRT3TDP1LIMK1 | |
| SCHEMBL7199668 | 0.76 | KDM4E (0.47) | NOS3NOS2ALOX15KMT2A | |
| SCHEMBL27956123 | 0.74 | KMT2A (0.39) | NOS3NOS2SIRT3TDP1LIMK1 | |
| SCHEMBL19439221 | 0.73 | SIRT3 (0.44) | SIRT3TDP1KMT2AMAPK1 | |
| SCHEMBL31408890 | 0.73 | MAP2K3 (0.42) | NOS3NOS2SIRT3TDP1LIMK1 | |
| SCHEMBL11870742 | 0.73 | SIRT3 (0.44) | NOS3NOS2SIRT3TDP1LIMK1 | |
| SCHEMBL17706554 | 0.73 | SIRT3 (0.44) | NOS3NOS2SIRT3TDP1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384741-B | A kind of salt and preparation method thereof of cyclin dependant kinase inhibitors | 诺华有限公司 | 2019-11-19 | — | — | CN | disclosed |