Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2745784 | 0.86 | HTR2B (0.49) | HTR2BCYP2C19ACHEALDH1A1LMNA | |
| SCHEMBL17761019 | 0.79 | CFTR (0.40) | HTR2BCYP2C19ACHEPLA2G4A | |
| SCHEMBL12169124 | 0.79 | HTR2B (0.50) | HTR2BCYP2C19ACHEALDH1A1LMNA | |
| SCHEMBL17711899 | 0.78 | MAPT (0.50) | ALDH1A1LMNAPLA2G4AP2RX7MAPT | |
| SCHEMBL15652132 | 0.77 | HTR2B (0.45) | HTR2BCYP2C19ACHEALDH1A1LMNA | |
| SCHEMBL14152154 | 0.77 | HTR2B (0.45) | HTR2BCYP2C19ACHEALDH1A1LMNA | |
| SCHEMBL2990831 | 0.76 | NR1I2 (0.52) | HTR2BACHEPLA2G4AMAPTGAA | |
| SCHEMBL231752 | 0.76 | GRM5 (0.53) | CYP2C19ALDH1A1LMNAP2RX7MAPT | |
| SCHEMBL107709 | 0.76 | S100A4 (0.48) | ALDH1A1P2RX7MAPTHTTGAA | |
| SCHEMBL17712058 | 0.75 | PLA2G4A (0.50) | HTR2BACHEALDH1A1PLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108064224-B | Amide-substituted thiazoles as modulators of Ror gamma t | 詹森药业有限公司 | 2022-03-29 | — | — | CN | disclosed |