Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645048 | 0.82 | — | — | |
| SCHEMBL10812480 | 0.78 | — | — | |
| Sulfuric Acid SCHEMBL10882768 | 0.78 | CA5A (0.46) | LMNATSHR | |
| SCHEMBL7637714 | 0.78 | — | — | |
| SCHEMBL12982911 | 0.78 | — | — | |
| Water SCHEMBL11586450 | 0.76 | CA5A (0.33) | TSHR | |
| Piperazine SCHEMBL27330293 | 0.76 | LMNA (0.46) | LMNACYP3A4GABRA1TSHRGABRG2 | |
| Piperazine SCHEMBL27671947 | 0.76 | LMNA (0.46) | LMNACYP3A4GABRA1TSHRGABRG2 | |
| Piperazine SCHEMBL11121855 | 0.76 | CYP3A4 (0.46) | LMNACYP3A4GABRA1TSHRGABRG2 | |
| SCHEMBL2585493 | 0.76 | CYP3A4 (0.46) | LMNACYP3A4GABRA1TSHRGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279378-A | Ophthalmic compositions comprising D2O | 西德奈克西斯公司 | 2022-11-01 | — | — | CN | disclosed |