SCHEMBL28879227

SCHEMBL28879227

Cn1ncc(=O)n(-c2ccccc2)c1=O

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 4/20 0.52
GSK3B P49841 4/20 0.52
ALDH1A1 P00352 9/20 0.44
ALDH1A3 P47895 8/20 0.42
ALDH1A2 O94788 7/20 0.42
PGR P06401 1/20 0.41
HTR1A P08908 1/20 0.40
ADRA1D P25100 1/20 0.40
ADRA1A P35348 1/20 0.40
ADRA1B P35368 1/20 0.40
HIF1A Q16665 1/20 0.40
GAA P10253 1/20 0.39
NPC1 O15118 1/20 0.39
PKM P14618 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28335228 0.84 HTR1A (0.39) GSK3AGSK3BALDH1A1ALDH1A3ALDH1A2
SCHEMBL28332874 0.77 GSK3B (0.45) GSK3AGSK3BALDH1A1PGRHTR1A
SCHEMBL11605447 0.69 GSK3A (0.45) GSK3AGSK3BALDH1A1HTR1AADRA1D
SCHEMBL3265646 0.69 GSK3A (0.45) GSK3AGSK3BALDH1A1PGRGAA
SCHEMBL31580031 0.69 GSK3B (0.55) GSK3AGSK3BPGRGAA
SCHEMBL16116340 0.69 GSK3A (0.50) GSK3AGSK3BALDH1A1PGRGAA
SCHEMBL7898559 0.69 HTR1A (0.36) ALDH1A1HTR1AADRA1DADRA1AADRA1B
SCHEMBL15354264 0.69 GSK3B (1.00) GSK3AGSK3BALDH1A1PGRGAA
SCHEMBL2611126 0.68 GSK3A (0.48) GSK3AGSK3BALDH1A1PGRGAA
SCHEMBL16919283 0.68 GSK3A (0.48) GSK3AGSK3BALDH1A1PGRNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105198861-B 6- acyl group -1,2,4- triazine -3,5- derovatives and herbicide FMC公司 2019-11-22 CN disclosed