Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471419 | 0.82 | NFE2L2 (0.45) | GSK3AGSK3BNFE2L2MAPTALDH1A1 | |
| SCHEMBL22349810 | 0.81 | MAPT (0.64) | GSK3AGSK3BMAPTALDH1A1HPGD | |
| SCHEMBL16197227 | 0.81 | NPC1 (0.44) | GSK3AGSK3BMAPTALDH1A1KDM4E | |
| SCHEMBL20644484 | 0.78 | ALDH1A1 (0.48) | MAPTALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL14280089 | 0.78 | MAPT (0.51) | GSK3AGSK3BMAPTALDH1A1CYP1A2 | |
| SCHEMBL7477352 | 0.77 | MAPT (0.39) | MAPTALDH1A1KDM4ESMN1; SMN2PPARG | |
| SCHEMBL22931495 | 0.76 | HTT (0.41) | GSK3AGSK3BMAPTALDH1A1CYP1A2 | |
| SCHEMBL22349850 | 0.76 | ALDH1A1 (0.47) | GSK3AGSK3BALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL14600370 | 0.76 | ROCK2 (0.50) | GSK3AGSK3BMAPTALDH1A1CYP1A2 | |
| SCHEMBL22931489 | 0.74 | KDM4E (0.44) | NFE2L2ALDH1A1KDM4ETDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025870-A1 | SYNERGISTIC COMBINATIONS OF THIADIAZOL CARBONIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2010-03-11 | — | — | WO | claimed |
| US-7166603-B2 | Dihydropyrimidone inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB CO. (US) | 2007-01-23 | — | — | US | disclosed |
| WO-2005009392-A2 | DIHYDROPYRIMIDONE INHIBITORS OF CALCIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-03 | — | — | WO | disclosed |