Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28331426 | 0.74 | LATS1 (0.45) | KDM4CRPS6KA5DYRK1ATBK1CLK1 | |
| SCHEMBL820570 | 0.68 | DYRK1A (0.47) | KDM4EKDM6BKDM5AKDM4CDYRK1A | |
| SCHEMBL24117380 | 0.67 | PDPK1 (0.36) | KDM4EKDM6BKDM5AKDM4CDYRK1A | |
| SCHEMBL15077818 | 0.65 | DYRK1A (0.44) | KDM4EKDM6BKDM5AKDM4CDYRK1A | |
| SCHEMBL15077824 | 0.63 | DYRK1A (0.43) | KDM4EKDM6BKDM5AKDM4CDYRK1A | |
| SCHEMBL5768942 | 0.63 | LATS1 (0.38) | KDM4CCLK1LATS1LATS2 | |
| SCHEMBL12501163 | 0.62 | IKBKE (0.56) | KDM4EKDM6BKDM5AKDM4CDYRK1A | |
| SCHEMBL20574445 | 0.62 | LATS1 (0.68) | LATS1LATS2 | |
| SCHEMBL250853 | 0.62 | ACHE (0.42) | KDM4CRPS6KA5CLK1LATS1LATS2 | |
| SCHEMBL15792325 | 0.62 | DYRK1A (0.49) | KDM4EKDM6BKDM5AKDM4CDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621222-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-06-14 | — | — | CN | claimed |
| CN-110573511-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2019-12-13 | — | — | CN | claimed |
| CN-114703144-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114621222-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-110573511-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2019-12-13 | — | — | CN | disclosed |