Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 11/20 | 0.38 |
| ▸ | LATS2 | Q9NRM7 | 10/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250853 | 0.73 | ACHE (0.42) | LATS1LATS2KDM4CACHELMNA | |
| SCHEMBL26157957 | 0.72 | DCPS (0.55) | ACHELMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29563950 | 0.72 | LATS1 (0.33) | LATS1LATS2KDM4CACHE | |
| SCHEMBL5768328 | 0.69 | HASPIN (0.46) | LATS1LATS2KDM4CACHELMNA | |
| SCHEMBL21875480 | 0.67 | LATS1 (0.61) | LATS1LATS2 | |
| SCHEMBL30007569 | 0.66 | KDM5A (0.46) | LATS1LATS2KDM4CACHELMNA | |
| SCHEMBL22716441 | 0.66 | DHFR (0.35) | — | |
| SCHEMBL20547728 | 0.66 | LATS1 (0.43) | LATS1LATS2KDM4CACHE | |
| SCHEMBL29439842 | 0.66 | DHFR (0.35) | — | |
| SCHEMBL25190902 | 0.65 | LATS1 (0.54) | LATS1LATS2KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006118598-A1 | BICYCLOHETEROARYLAMINE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF | RENOVIS, INC. (US) | 2006-11-09 | — | — | WO | claimed |
| EP-1697361-A1 | BICYCLOHETEROARYLAMINE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF | Renovis, Inc. (US) | 2006-09-06 | — | — | EP | claimed |
| WO-2005066171-A1 | BICYCLOHETEROARYLAMINE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF | RENOVIS, INC. (US) | 2005-07-21 | — | — | WO | claimed |