Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632807 | 0.98 | LMNA (0.62) | LMNAMAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL196919 | 0.98 | LMNA (0.62) | LMNAMAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL196920 | 0.98 | LMNA (0.62) | LMNAMAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL8997409 | 0.91 | LMNA (0.56) | LMNAMAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL275597 | 0.85 | LMNA (0.79) | LMNAMAPK1NPSR1BLMTSHR | |
| SCHEMBL19735013 | 0.77 | HDAC3 (0.45) | LMNAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11218186 | 0.77 | HDAC3 (0.45) | LMNAMAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL4092644 | 0.77 | HDAC3 (0.45) | LMNAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL531658 | 0.77 | HDAC3 (0.45) | LMNAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1957930 | 0.76 | LMNA (0.65) | LMNAMAPK1NPSR1BLMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110382494-A | Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2019-10-25 | — | — | CN | disclosed |