SCHEMBL28881990

SCHEMBL28881990

C#Cc1cccc(-c2cccnc2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.56
ALDH1A1 P00352 2/20 0.56
CYP1A2 P05177 1/20 0.56
CYP3A4 P08684 1/20 0.56
MEN1 O00255 1/20 0.55
PSIP1 O75475 1/20 0.55
AXL P30530 1/20 0.55
MKNK1 Q9BUB5 1/20 0.55
MKNK2 Q9HBH9 1/20 0.55
CYP11B2 P19099 8/20 0.49
CYP11B1 P15538 7/20 0.49
CYP17A1 P05093 3/20 0.49
CYP19A1 P11511 3/20 0.49
KMO O15229 1/20 0.49
EPHX2 P34913 1/20 0.46
PRMT6 Q96LA8 1/20 0.46
CHRNB2 P17787 1/20 0.46
CHRNA5 P30532 1/20 0.46
CHRNA4 P43681 1/20 0.46
DYRK1A Q13627 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29984880 1.00 CYP2A6 (0.56) CYP2A6ALDH1A1CYP1A2CYP3A4MEN1
SCHEMBL8274296 0.83 ATM (0.48) CYP2A6MEN1PSIP1AXLMKNK1
SCHEMBL3841296 0.82 CA12 (0.48) CYP3A4MEN1
SCHEMBL29809001 0.81 CYP11B2 (0.71) CYP2A6ALDH1A1CYP1A2CYP3A4MEN1
SCHEMBL13537172 0.81 CYP11B2 (0.71) CYP2A6ALDH1A1CYP1A2CYP3A4MEN1
SCHEMBL15450295 0.81 CYP11B2 (0.67) CYP2A6ALDH1A1CYP1A2CYP3A4MKNK1
SCHEMBL16108938 0.80 CYP2A6 (0.54) CYP2A6ALDH1A1CYP1A2CYP3A4MEN1
SCHEMBL30620885 0.80 CYP2A6 (0.79) CYP2A6ALDH1A1CYP1A2CYP3A4MEN1
SCHEMBL17951830 0.80 CYP2A6 (0.79) CYP2A6ALDH1A1CYP1A2CYP3A4MEN1
SCHEMBL12103445 0.80 CYP2A6 (0.79) CYP2A6ALDH1A1CYP1A2CYP3A4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115304495-A Phenanthrene derivative and application thereof 北京八亿时空液晶科技股份有限公司 2022-11-08 CN disclosed