Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 13/20 | 0.79 |
| ▸ | JAK2 | O60674 | 11/20 | 0.79 |
| ▸ | JAK1 | P23458 | 7/20 | 0.79 |
| ▸ | JAK3 | P52333 | 7/20 | 0.79 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28362636 | 0.99 | TYK2 (0.78) | TYK2JAK2JAK1JAK3NTRK1 | |
| SCHEMBL29551892 | 0.92 | TYK2 (0.67) | TYK2JAK2JAK1JAK3NTRK1 | |
| SCHEMBL28359080 | 0.90 | TYK2 (0.64) | TYK2JAK2JAK1JAK3NTRK1 | |
| SCHEMBL29922629 | 0.90 | TYK2 (0.64) | TYK2JAK2JAK1JAK3NTRK1 | |
| SCHEMBL28359087 | 0.89 | TYK2 (1.00) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28362694 | 0.87 | TYK2 (0.63) | TYK2JAK2JAK1JAK3BTK | |
| Hydrochloric Acid SCHEMBL28362690 | 0.87 | TYK2 (0.62) | TYK2JAK2JAK1JAK3BTK | |
| SCHEMBL29551995 | 0.83 | JAK2 (0.69) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL28359167 | 0.83 | JAK2 (0.69) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL28362757 | 0.81 | JAK2 (0.71) | TYK2JAK2JAK1JAK3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |