Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 13/20 | 0.67 |
| ▸ | JAK2 | O60674 | 10/20 | 0.67 |
| ▸ | JAK1 | P23458 | 6/20 | 0.67 |
| ▸ | JAK3 | P52333 | 6/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28884127 | 0.92 | TYK2 (0.79) | TYK2JAK2JAK1JAK3NTRK1 | |
| Hydrochloric Acid SCHEMBL28362636 | 0.91 | TYK2 (0.78) | TYK2JAK2JAK1JAK3NTRK1 | |
| SCHEMBL28359080 | 0.91 | TYK2 (0.64) | TYK2JAK2JAK1JAK3NTRK1 | |
| SCHEMBL29922629 | 0.91 | TYK2 (0.64) | TYK2JAK2JAK1JAK3NTRK1 | |
| SCHEMBL29552183 | 0.88 | TYK2 (0.85) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL28359087 | 0.80 | TYK2 (1.00) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29552228 | 0.80 | TYK2 (0.61) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL28359040 | 0.79 | TYK2 (0.81) | TYK2JAK2JAK1JAK3RXFP1 | |
| SCHEMBL28359167 | 0.78 | JAK2 (0.69) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL29551995 | 0.78 | JAK2 (0.69) | TYK2JAK2JAK1JAK3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |