Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 16/20 | 0.72 |
| ▸ | BCHE | P06276 | 11/20 | 0.72 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.72 |
| ▸ | GRIN2A | Q12879 | 11/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30023055 | 1.00 | ACHE (0.72) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL29023217 | 0.98 | ACHE (0.73) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL30356238 | 0.98 | ACHE (0.73) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL29023229 | 0.95 | ACHE (0.73) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL29023219 | 0.86 | ACHE (0.73) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL18065461 | 0.84 | ACHE (0.73) | ACHEBCHEGRIN1GRIN2AMAPT | |
| Hydrochloric Acid SCHEMBL29817717 | 0.84 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ASLC2A1 | |
| SCHEMBL30397413 | 0.83 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ASLC2A1 | |
| SCHEMBL28998722 | 0.83 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ASLC2A1 | |
| SCHEMBL2126156 | 0.83 | ACHE (0.74) | ACHEBCHEGRIN1GRIN2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115124511-B | Tacrine derivatives, preparation method thereof and application of tacrine derivatives as CDK2/9 inhibitor | 中国人民解放军北部战区总医院 | 2023-09-26 | — | — | CN | disclosed |
| CN-115160298-B | Tacrine-sulfonamide derivative and preparation method and application thereof | 中国人民解放军北部战区总医院 | 2023-05-23 | — | — | CN | disclosed |
| CN-115160298-A | Tacrine-sulfonamide derivative and preparation method and application thereof | 中国人民解放军北部战区总医院 | 2022-10-11 | — | — | CN | disclosed |