Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 13/20 | 0.73 |
| ▸ | BCHE | P06276 | 8/20 | 0.60 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.60 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30356238 | 0.88 | ACHE (0.73) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL29023217 | 0.88 | ACHE (0.73) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL28885703 | 0.86 | ACHE (0.72) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL30023055 | 0.86 | ACHE (0.72) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL29023229 | 0.84 | ACHE (0.73) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL28998061 | 0.84 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ACHRM1 | |
| SCHEMBL4266767 | 0.84 | ACHE (0.74) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL13885355 | 0.78 | ACHE (0.75) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL9254247 | 0.78 | MAPT (0.52) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL18705826 | 0.78 | MAPT (0.53) | ACHEBCHEMAPTCHRM1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853672-B | Tacrine derivatives as CDKs inhibitors and uses thereof | 中国人民解放军北部战区总医院 | 2023-06-23 | — | — | CN | disclosed |
| CN-114853672-A | Tacrine derivatives as CDKs inhibitors and application thereof | 中国人民解放军北部战区总医院 | 2022-08-05 | — | — | CN | disclosed |