SCHEMBL2888751

SCHEMBL2888751

O=C(NCO)c1ccccc1C(F)(F)F

nearest known ligand 0.69

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.66
GAA P10253 1/20 0.66
KCNK3 O14649 3/20 0.50
KCNK9 Q9NPC2 3/20 0.50
PTGS1 P23219 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CTNNB1 P35222 1/20 0.50
WNT3A P56704 1/20 0.50
HDAC3 O15379 1/20 0.49
HDAC1 Q13547 1/20 0.49
P2RX7 Q99572 1/20 0.48
F2R P25116 1/20 0.48
PPIA P62937 1/20 0.48
PTPRC P08575 1/20 0.47
RXFP1 Q9HBX9 1/20 0.46
RECQL P46063 1/20 0.46
THRB P10828 1/20 0.45
PTGES O14684 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30748278 1.00 LMNA (0.66) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL4007613 0.86 GAA (0.62) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL16711780 0.84 LMNA (0.64) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL5720709 0.84 LMNA (0.64) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL23014140 0.82 GAA (0.57) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL7396599 0.82 HDAC3 (0.59) LMNAGAAHDAC3HDAC1THRB
SCHEMBL10946343 0.82 LMNA (0.43) LMNAGAA
SCHEMBL1128084 0.81 LMNA (0.70) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL20966218 0.81 LMNA (0.60) LMNAGAAKCNK3KCNK9PTGS1
SCHEMBL14206037 0.81 LMNA (0.60) LMNAGAAKCNK3KCNK9PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118561746-A Fluopicola strain method for synthesizing amide 闽江学院 2024-08-30 CN disclosed
CN-117417293-B Synthesis method of fluopyram 齐鲁晟华制药有限公司 2024-03-19 CN disclosed
CN-117417293-A Synthesis method of fluopyram 齐鲁晟华制药有限公司 2024-01-19 CN disclosed
CN-111056997-A Synthetic method of benzamide compound 西安近代化学研究所 2020-04-24 CN disclosed
EP-2873658-B1 OXIME-SUBSTITUTED AMIDE COMPOUND AND PEST CONTROL AGENT NISSAN CHEMICAL IND LTD (JP) 2018-09-05 EP disclosed
US-9920046-B2 Oxime-substituted amide compound and pest control agent NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2018-03-20 US disclosed
US-20160318919-A1 OXIME-SUBSTITUTED AMIDE COMPOUND AND PEST CONTROL AGENT NISSAN CHEMICAL INDUSTRIES, LTD (JP) 2016-11-03 US disclosed
US-9434684-B2 Oxime-substituted amide compound and pest control agent NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2016-09-06 US disclosed
US-20150210630-A1 OXIME-SUBSTITUTED AMIDE COMPOUND AND PEST CONTROL AGENT NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-07-30 US disclosed
EP-2873658-A1 OXIME-SUBSTITUTED AMIDE COMPOUND AND PEST CONTROL AGENT Nissan Chemical Industries, Ltd. (JP) 2015-05-20 EP disclosed
CN-104428282-A Oxime-substituted amide compound and pest control agent NISSAN CHEMICAL IND LTD 2015-03-18 CN disclosed
US-8865908-B2 Process for the preparation of a 2-pyridylethylcarboxamide derivative BAYER CROPSCIENCE AG (DE) 2014-10-21 US disclosed
US-20100292485-A1 PROCESS FOR THE PREPARATION OF A 2-PYRIDYLETHYLCARBOXAMIDE DERIVATIVE BAYER CROPSCIENCE S.A. (FR) 2010-11-18 US disclosed
CN-101080391-B Process for the preparation of a 2-pyridylethylcarboxamide derivative BAYER CROPSCIENCE SA 2010-09-22 CN disclosed
US-7790901-B2 N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide; starting with a halogenobenzoyl derivative to produce a N-acetoxymethylcarboxamide derivative and then coupling it with a 2-pyridyl acetate derivative; pesticide BAYER CROPSCIENCE S.A. (FR) 2010-09-07 US disclosed
US-20080086008-A1 N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide; starting with a halogenobenzoyl derivative to produce a N-acetoxymethylcarboxamide derivative and then coupling it with a 2-pyridyl acetate derivative; pesticide BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-04-10 US disclosed
CN-101080391-A Process for the preparation of a 2-pyridylethylcarboxamide derivative BAYER CROPSCIENCE SA (FR) 2007-11-28 CN disclosed
EP-1831169-A2 PROCESS FOR THE PREPARATION OF A 2-PYRIDYLETHYLCARBOXAMIDE DERIVATIVE Bayer CropScience S.A. (FR) 2007-09-12 EP disclosed
WO-2006067103-A2 PROCESS FOR THE PREPARATION OF A 2-PYRIDYLETHYLCARBOXAMIDE DERIVATIVE BAYER CROPSCIENCE SA (FR) 2006-06-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080086008-A1 N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide; starting with a halogenobenzoyl derivative to produce a N-acetoxymethylcarboxamide derivative and then coupling it with a 2-pyridyl acetate derivative; pesticide DDT, PFAS, AADAC LMNA 1518/4885GAA 844/4885KCNK3 299/4885
US-20160318919-A1 OXIME-SUBSTITUTED AMIDE COMPOUND AND PEST CONTROL AGENT CHRM1, CHRM2, CHRM4 LMNA 3021/4885GAA 4209/4885KCNK3 878/4885
US-20100292485-A1 PROCESS FOR THE PREPARATION OF A 2-PYRIDYLETHYLCARBOXAMIDE DERIVATIVE GBA2, CPS1, CYP4F2 LMNA 1092/4885GAA 220/4885KCNK3 1598/4885
US-20150210630-A1 OXIME-SUBSTITUTED AMIDE COMPOUND AND PEST CONTROL AGENT CHRM1, CHRM2, CHRM4 LMNA 3021/4885GAA 4209/4885KCNK3 878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.