Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.39 |
| ▸ | JAK2 | O60674 | 10/20 | 0.39 |
| ▸ | JAK1 | P23458 | 9/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29522964 | 1.00 | JAK3 (0.39) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL29523539 | 0.91 | JAK3 (0.44) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL28887556 | 0.88 | JAK1 (0.43) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL28887529 | 0.87 | JAK3 (0.52) | JAK3JAK2JAK1TYK2AURKA | |
| SCHEMBL28887603 | 0.86 | JAK2 (0.51) | JAK3JAK2JAK1TYK2KDR | |
| SCHEMBL28887601 | 0.85 | JAK1 (0.55) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL29523014 | 0.81 | IGF1R (0.40) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL28887524 | 0.78 | JAK3 (0.59) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL28887604 | 0.78 | JAK1 (0.38) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL28887507 | 0.75 | JAK2 (0.41) | JAK3JAK2JAK1TYK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | claimed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | disclosed |